Osteogenesis Imperfecta

Osteogenesis imperfecta Osteogenesis imperfecta (OI) is a r atomic number 18 genetic disorder of collagen synthesis associated with all-inclusive spectrum of musculoskeletal problems, most notably bowing and fractures of the extremities, muscle weakness, lassitude in the ligaments, and spinal deformities.(Binder, 386). separate collagen-containing skeletal tissues, such as the sclerae, the teeth, and the heart valves atomic number 18 as well as affected to a variable amount of money degree. OI has a common feature of bony fragility associated with punk formation of collagen by osteoblasts and fibroblasts(Smith, 1983, 13).

This disease, involv ing defective development of the connective tissues, is normally the result of the autosomal dominant gene, but can as well be the result of the autosomal recessive gene. Spontaneous mutations are common and the clinical presentation of the disease remains to be quite broad (Binder, 386). OI is most commonly referred to as unannealed bones,” but other names include: fragilitas o...If you want to make a full essay, order it on our website: OrderEssay.net

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